I Barry Holland,Susan P. C. Cole,Karl Kuchler, et's ABC Proteins. From Bacteria to Man PDF

By I Barry Holland,Susan P. C. Cole,Karl Kuchler, et al.Elsevier|Elsevier Science||Academic PressAdult NonfictionScienceLanguage(s): EnglishOn sale date: 13.10.2011Street date: 07.01.2003

ISBN-10: 0080481876

ISBN-13: 9780080481876

ABC Proteins is an in-depth, up to date research of all that's recognized concerning the topic thus far. It discusses and compares evolution, biology and mechanism of motion of all recognized ABC proteins, together with the 1st structural reviews in addition to medical implications. it will likely be worthwhile to a person attempting to remain abreast of the newest findings. This e-book is certain to develop into a vintage and should on a regular basis be updated.

Key Features

  • Phylogeny and Evoloution of ABC Transporters
  • Fundamental facets of the Mechanism of motion of ABC Transporters
  • Prokaryote ABC Transporters
  • Non-Mammalian Transporters
  • Multidrug Transporters
  • ABC Transporters, Physiological Roles and Human Disease
  • Full colour all through
  • Show description

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    Extra info for ABC Proteins. From Bacteria to Man

    Example text

    Uk, University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK Anne T. ca, Centre de Recherche en Infectiologie and Département de Biologie médicale, Université Laval, 2705, boul. edu, Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA Gerrit J. nl, Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands Philip A.

    For many ABC transporters auxiliary domains have been recruited to add on specific functions. In bacterial uptake systems the periplasmic binding proteins (PBPs) bind substrate outside the cell membrane and deliver it to the membrane-associated transport complex (Wilkinson and Verschueren, Chapter 10). The PBPs have two distinct but related functions: (a) To impart high affinity and specificity – binding protein-dependent transporters often show remarkably high affinity and specificity compared with transporters which lack such a component.

    1 Unrooted simplified phylogenetic tree of ABC proteins and domains. For the sake of clarity, only the branches pointing to families have been drawn. The major subdivisions of the tree are indicated according to the nomenclature used in the text. ); class 3: systems with IM and ABC domains carried by independent polypeptide chains (BPD importers and other systems). Under the name of the class, the minimal consensus organization of ABC systems is represented by colored symbols in a linear fashion.

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    ABC Proteins. From Bacteria to Man by I Barry Holland,Susan P. C. Cole,Karl Kuchler, et al.Elsevier|Elsevier Science||Academic PressAdult NonfictionScienceLanguage(s): EnglishOn sale date: 13.10.2011Street date: 07.01.2003


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