By Neal L. Benowitz (auth.), Howard D. Cappell, Frederick B. Glaser, Yedy Israel, Harold Kalant, Wolfgang Schmidt, Edward M. Sellers, Reginald C. Smart (eds.)
This, the 9th quantity within the sequence, looks a few thirteen years after the 1st. Like so much of its predecessors, quantity nine is intentionally eclectic, protecting a number of themes that the editors imagine invaluable of inclusion. many of the chapters, reminiscent of the evaluation of the literature on benzodiazepines, characterize parts that experience acquired rather little cognizance in prior volumes-largely as the literature has no longer formerly been "ripe" for assessment. Others signify literatures which were reviewed long ago yet which proceed to enhance in enough degree that their ripening by no means ceases. Shepard Siegel's contribution represents a relative rarity in earlier volumes: a bankruptcy now not encumbered with a attention of present empirical paintings, yet a reflective essay designed to stir inspiration with a few professional vocative principles. The editors belief that readers will proceed to discover learn Advances to be an enormous repository of information within the alcohol and drug fields. The Editors Toronto IX Contents 1. THE HUMAN PHARMACOLOGY OF NICOTINE Neal L. Benowitz 1. advent 2. Nicotine in Tobacco items 2 three. Phannacokinetics of Nicotine four four. Nicotine and Cotinine Blood degrees in the course of Tobacco Use 14 five. consumption of Nicotine in the course of Cigarette Smoking 18 6. Biochemical Markers of Nicotine consumption 18 7. law of Nicotine consumption in the course of Cigarette Smoking 23 eight. Phannacology of Nicotine 28 nine. value of Nicotine in Human disorder forty-one References forty five 2. BENZODIAZEPINES AS medications OF ABUSE AND DEPENDENCE fifty three Howard D. Cappell, Edward M. , and Usoa Busto 1.
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This, the 9th quantity within the sequence, appears to be like a few thirteen years after the 1st. Like such a lot of its predecessors, quantity nine is intentionally eclectic, overlaying quite a number issues that the editors imagine helpful of inclusion. a number of the chapters, equivalent to the evaluation of the literature on benzodiazepines, symbolize components that experience got particularly little awareness in earlier volumes-largely as the literature has now not formerly been "ripe" for evaluate.
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1. 2:357-360. , Marsh, V. , Millman, J. , Rawlins, M. , and Thompson, J. V. nicotine in man, Br. 1. Clin. Pharmacol. 10:579-589. , 1981, Effect of nicotine sulfate on the hemodynamics and acid base balance of chronically instrumented pregnant sheep, Dev. Pharmacol. Ther. 3:205-213. Bargeron, L. , and Bing, R. , 1957, Effect of cigarette smoking on coronary blood flow and myocardial metabolism, Circulation 15:251-257. Beckett, A. , and Triggs, E. , 1965, Significance of smoking in investigations of urinary excretion rates of amines in man, Nature 207:200-201.
The reinforcing role of nicotine as a drug of abuse has been investigated by Henningfield et al. (1983). 0 mg per injection, each given over 10 sec. They found that the number of doses taken by subjects was inversely related to the dose of the drug per injection. Subjects described the subjective responses to nicotine as similar to the morphine groups of drugs. Subjects with previous drug abuse histories described the effects of nicotine as similar to those of cocaine. In some, the injections of nicotine produced dysphoric effects that limited the number of injections taken.
Haymond, M. , Santiago, 1. , and Shah, S. , 1976, Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events, N. Engl. J. Med. 295:573-577. Dingman, 1. , and Thorn, G. , 1957, Studies of neurohypophyseal function in man, Am. J. Med. 23:226. Domino, E. , 1979, Behavioral, electrophysiological, endocrine, and skeletal muscle actions of nicotine and tobacco smoking, in: Electrophysiological Effects of Nicotine (A. Remond and C. ), pp. 133-146, ElsevierlNorth-Holland Biomedical Press, Amsterdam.
Research Advances in Alcohol and Drug Problems by Neal L. Benowitz (auth.), Howard D. Cappell, Frederick B. Glaser, Yedy Israel, Harold Kalant, Wolfgang Schmidt, Edward M. Sellers, Reginald C. Smart (eds.)