By Caroline Gordon, David Isenberg
Systemic Lupus Erythematosus offers a pragmatic method of the overview and administration of sufferers with this complicated, multisystem autoimmune affliction to enhance the prognosis and remedy of the affliction and its complications.
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Systemic Lupus Erythematosus presents a realistic method of the overview and administration of sufferers with this complicated, multisystem autoimmune affliction to enhance the analysis and therapy of the illness and its issues. summary: Systemic Lupus Erythematosus presents a realistic method of the review and administration of sufferers with this complicated, multisystem autoimmune affliction to enhance the analysis and remedy of the sickness and its issues.
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Extra info for Systemic lupus erythematosus
2 Important immunologic pathways in the pathogenesis of SLE as highlighted by the identified susceptibility genes. Abbreviations: IFN, interferon; NF-κB, nuclear factor kappa B; TLR, toll-like receptor: Reprinted from Dubois’ Lupus Erythematosus and Related Syndromes, 8th Edition, Wallace and Hahn, Chapter 4: Genetics of Human SLE; Deng and Tsao, copyright (203) with permission from Elsevier. 2 Epigenetic modifications, which direct the folding and unfolding of DNA, alter the availability of gene expression at each level of organization.
8/00,000). 5/00,000). 0 compared with the relevant local population. The original reports on mortality in SLE in the 950s suggested that only 50% of lupus patients survived 4 years. With earlier diagnosis, improved treatment, and monitoring of the disease and comorbidities, the survival rate has improved over the last 60 years. But it should be remembered that mortality has reduced in general, with figures of up to 70% reduction in mortality in the general population in the US between 965 and 2005, largely due to a reduction in deaths from heart attacks and strokes.
Up to 75% of patients with SLE (from all ethnicities) have at least one predisposing HLA gene polymorphism. Polymorphisms within HLA-DR2 and -DR3 are strongly associated with disease in white Europeans and European Americans. 8 times higher compared with wild-type carriers. 2 Predisposing genes encoding for proteins in innate immune pathways include those involved with toll-like receptor pathways, interferon signalling, and nuclear factor-kappaB (NF-βB) signalling. These mutations ultimately lead to the enhanced interferon alpha signature that is characteristic of SLE.
Systemic lupus erythematosus by Caroline Gordon, David Isenberg